Association of fetal-derived hypermethylated RASSF1A concentration in placenta-mediated pregnancy complications

• Published in: Placenta (Eastbourne) Vol. 34; no. 1; pp. 57 - 61
• Main Authors: Kim, M.J., Kim, S.Y., Park, S.Y., Ahn, H.K., Chung, J.H., Ryu, H.M.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2013; Elsevier
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; DNA Methylation - physiology; Embryology: invertebrates and vertebrates. Teratology; Female; Fetal Growth Retardation - blood; Fetal Growth Retardation - genetics; Fetal Growth Retardation - metabolism; Fetal-derived hypermethylated RASSF1A sequence; Fetus - metabolism; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Developmental - physiology; Gestational Age; Humans; Infant, Newborn; Internal Medicine; Intrauterine growth restriction; Male; Maternal plasma; Obstetrics and Gynecology; Osmolar Concentration; Placenta - metabolism; Placenta - pathology; Placenta - physiology; Placenta Diseases - blood; Placenta Diseases - genetics; Placenta Diseases - metabolism; Placenta Diseases - pathology; Placenta Previa - blood; Placenta Previa - genetics; Placenta Previa - metabolism; Placental dysfunction; Placental previa; Pre-Eclampsia - blood; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Pregnancy Complications - blood; Pregnancy Complications - etiology; Pregnancy Complications - genetics; Pregnancy Complications - metabolism; Tumor Suppressor Proteins - analysis; Tumor Suppressor Proteins - blood; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Maternal plasma; Intrauterine growth restriction; Fetal-derived hypermethylated RASSF1A sequence; Placental previa; Preeclampsia; Placental dysfunction; Pregnancy; Vertebrata; Mammalia; Placenta; Fetal membrane; Complication; Fetus

To assess whether fetal-derived hypermethylated RASSF1A concentrations in maternal plasma during pregnancy are altered in pregnancies associated with placental dysfunction manifested by intrauterine growth restriction (IUGR), preeclampsia (PE), or placental previa (PP) and whether this alteration ca...