Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

• Published in: The Journal of neuroscience Vol. 38; no. 3; pp. 530 - 543
• Main Authors: Maass, Anne, Lockhart, Samuel N., Harrison, Theresa M., Bell, Rachel K., Mellinger, Taylor, Swinnerton, Kaitlin, Baker, Suzanne L., Rabinovici, Gil D., Jagust, William J.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 17.01.2018
• Subjects: Accumulation; Adults; Age; Aged; Aged, 80 and over; Aging; Aging - metabolism; Aging - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Atrophy; Autopsy; Cognition; Cognitive ability; Cortex (entorhinal); Dementia disorders; Emission analysis; Entorhinal Cortex - metabolism; Entorhinal Cortex - pathology; Female; Humans; In vivo methods and tests; Magnetic Resonance Imaging; Male; Memory; Memory Disorders - metabolism; Memory Disorders - pathology; Memory, Episodic; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurodegeneration; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - pathology; Older people; Parahippocampal gyrus; Pathology; Positron emission; Positron emission tomography; Tau protein; tau Proteins - metabolism; Tauopathies - metabolism; Tauopathies - pathology; Temporal cortex; Temporal lobe; β-Amyloid; episodic memory; tau; transentorhinal cortex; aging; positron emission tomography; β-amyloid

The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic-memory decline in aging and dementia. Postmortem data indicate that tau pathology in the transentorhinal cortex is common by age 60, whereas spread to neocortical regions and worsening of co...