Complete Genome Sequence, Molecular Characterization and Phylogenetic Relationships of a Novel Tern Atadenovirus

• Published in: Microorganisms (Basel) Vol. 10; no. 1; p. 31
• Main Authors: Matsvay, Alina, Dyachkova, Marina, Mikhaylov, Ivan, Kiselev, Daniil, Say, Anna, Burskaia, Valentina, Artyushin, Ilya, Khafizov, Kamil, Shipulin, German
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.12.2021; MDPI
• Subjects: Adenoviridae; Adenoviruses; Aquatic birds; Atadenovirus; Coronaviruses; COVID-19; Deoxyribonucleic acid; Divergence; DNA; Epidemics; genome annotation; Genomes; Infectious diseases; Influenza; Methionine; Migratory birds; Nucleotide sequence; Nucleotides; Open reading frames; Pandemics; Pathogens; Phylogenetics; Phylogeny; Proteins; Severe acute respiratory syndrome coronavirus 2; Taxonomy; tern atadenovirus 1; Viral infections; Viruses; United States > US; Russia; phylogenetics; Adenoviridae; Atadenovirus; tern atadenovirus 1; genome annotation
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms10010031

Discovery and study of viruses carried by migratory birds are tasks of high importance due to the host's ability to spread infectious diseases over significant distances. With this paper, we present and characterize the first complete genome sequence of atadenovirus from a tern bird (common tern, ) preliminarily named tern atadenovirus 1 (TeAdV-1). TeAdV-1 genome is a linear double-stranded DNA molecule, 31,334 base pairs which contain 30 methionine-initiated open reading frames with gene structure typical for genus, and the shortest known inverted terminal repeats (ITRs) within the genus consisted of 25 bases. The nucleotide composition of the genome is characterized by a low G + C content (33.86%), which is the most AT-rich genome of known avian adenoviruses within genus. The nucleotide sequence of the TeAdV-1 genome shows high divergence compared to known representatives of the genus with the highest similarity to the duck atadenovirus 1 (53.7%). Phylogenetic analysis of the protein sequences of core genes confirms the taxonomic affiliation of the new representative to the genus with the degree of divergence from the known representatives exceeding the interspecies distance within the genus. Thereby we proposed a novel TeAdV-1 to be considered as a separate species.