Properties of An Oral Nanoformulation of A Molecularly Dispersed Amphotericin B Comprising A Composite Matrix of Theobroma Oil and Bee'S Wax

• Published in: Nanomaterials (Basel, Switzerland) Vol. 4; no. 4; pp. 905 - 916
• Main Authors: Tan, Chloe See Wei, Billa, Nashiru, Roberts, Clive J, Scurr, David J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.12.2014; MDPI
• Subjects: amphotericin B (AmB); Beeswax; Bioavailability; cellular uptake; Dispersion; Drug delivery systems; Encapsulation; Fungal infections; lipid; Lipids; Lymph; Nanomaterials; Nanoparticles; Nanostructure; Oral administration; Pharmacy; Shells; Spectrum analysis; theobroma oil; Uptakes; United Kingdom > UK; Malaysia; amphotericin B (AmB); nanoparticles; beeswax; lipid; theobroma oil; cellular uptake

An amphotericin B-containing (AmB) solid lipid nanoparticulate drug delivery system intended for oral administration, comprised of bee's wax and theobroma oil as lipid components was formulated with the aim to ascertain the location of AmB within the lipid matrix: (a) a homogenous matrix; (b) a...