Cell Death of Melanophores in Zebrafish trpm7 Mutant Embryos Depends on Melanin Synthesis

• Published in: Journal of investigative dermatology Vol. 127; no. 8; pp. 2020 - 2030
• Main Authors: McNeill, Matthew S., Paulsen, Jennifer, Bonde, Gregory, Burnight, Erin, Hsu, Mei-Yu, Cornell, Robert A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2007; Elsevier Limited
• Subjects: Animals; Apoptosis; Caspase Inhibitors; Cell death; Cell Line, Tumor; Cell Survival; Danio rerio; Embryo, Nonmammalian - cytology; Freshwater; Magnesium - pharmacology; Melanins - biosynthesis; Melanoma - chemistry; Melanophores - cytology; Mutation; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins c-kit - physiology; TRPM Cation Channels - analysis; TRPM Cation Channels - genetics; TRPM Cation Channels - physiology; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - physiology; Zebrafish; Zebrafish Proteins - analysis; Zebrafish Proteins - genetics; Zebrafish Proteins - physiology

Transient receptor potential melastatin 7 (TRPM7) is a broadly expressed, non-selective cation channel. Studies in cultured cells implicate TRPM7 in regulation of cell growth, spreading, and survival. However, zebrafish trpm7 homozygous mutants display death of melanophores and temporary paralysis,...