RFX transcription factors are essential for hearing in mice

• Published in: Nature communications Vol. 6; no. 1; p. 8549
• Main Authors: Elkon, Ran, Milon, Beatrice, Morrison, Laura, Shah, Manan, Vijayakumar, Sarath, Racherla, Manoj, Leitch, Carmen C., Silipino, Lorna, Hadi, Shadan, Weiss-Gayet, Michèle, Barras, Emmanuèle, Schmid, Christoph D., Ait-Lounis, Aouatef, Barnes, Ashley, Song, Yang, Eisenman, David J., Eliyahu, Efrat, Frolenkov, Gregory I., Strome, Scott E., Durand, Bénédicte, Zaghloul, Norann A., Jones, Sherri M., Reith, Walter, Hertzano, Ronna
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.10.2015; Nature Publishing Group
• Subjects: 13/31; 13/51; 14/19; 14/28; 38/39; 38/90; 49/91; 631/136; 631/378/2619/1533; 631/45/612/822; 64/110; 64/116; 64/60; Animals; Animals, Newborn; Biological Evolution; Chromatin Immunoprecipitation; DNA-Binding Proteins - metabolism; Female; Gene Expression Regulation; Hair Cells, Auditory - metabolism; Hair Cells, Auditory - ultrastructure; Hearing - physiology; Humanities and Social Sciences; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; multidisciplinary; Multigene Family; Regulatory Factor X Transcription Factors; Regulatory Factor X1; Science; Science (multidisciplinary); Sequence Analysis, DNA; Transcription Factors - metabolism; Transcriptome; Zebrafish

Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development h...