Overexpression of cytochrome P450 genes in pyrethroid-resistant Culex quinquefasciatus

• Published in: Insect biochemistry and molecular biology Vol. 40; no. 2; pp. 146 - 152
• Main Authors: Komagata, Osamu, Kasai, Shinji, Tomita, Takashi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2010
• Subjects: adult insects; Animals; Base Sequence; complementary DNA; Culex; Culex - genetics; Culex quinquefasciatus; cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450 monooxygenase, Insecticide resistance; gene expression regulation; genetics; hematophagous insects; imagos; insect pests; insect vectors; Insecticide Resistance; larvae; metabolic detoxification; Microarray; microarray technology; microsomes; molecular sequence data; nucleotide sequences; oxygenases; Pyrethrins; Pyrethroid; pyrethroid insecticides; strain differences; transcription (genetics); INW, Japan; Pyrethroid; Microarray; Cytochrome P450 monooxygenase, Insecticide resistance; Culex quinquefasciatus

JPal-per strain of Culex quinquefasciatus exhibits extremely high resistance against pyrethroids in larvae, though the resistance is greatly lower in adults. Increased microsome monooxygenase metabolism is one of the major factors of the larval resistance in this strain. We cloned 46 novel cytochrom...