Improvement of human faecal flora-associated mouse model for evaluation of the functional foods

• Published in: Journal of applied microbiology Vol. 96; no. 4; pp. 656 - 663
• Main Authors: Imaoka, A, Setoyama, H, Takagi, A, Matsumoto, S, Umesaki, Y
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2004; Blackwell Science; Oxford University Press
• Subjects: Acetates - analysis; animal models; Animals; bacteria; Bacteria - isolation & purification; Biological and medical sciences; Dietary Supplements; enzyme activity; Evaluation Studies as Topic; feces; Feces - microbiology; Flora; functional food; functional foods; Functional foods & nutraceuticals; Fundamental and applied biological sciences. Psychology; human flora‐associated mouse; Humans; immunoglobulins; immunological response; intestinal microorganisms; intestine; intestines; Intestines - immunology; Intestines - metabolism; Intestines - microbiology; Lactobacillus; lymphocytes; major histocompatibility complex; metabolism; Mice; Mice, Inbred BALB C; Microbiology; Models, Animal; mucosa; prebiotics; Probiotics; Propionates - analysis; rearing; segmented filamentous bacteria; Human; Animal model; Health food; Applied microbiology; Feces; Associated flora; Optimization

Aims: Animal models are required for evaluation of the functional foods such as pro/prebiotics exerting effects through the metabolism of the intestinal microflora. The object of this study was to establish new human flora-associated mice reflecting the environment of the human intestinal tract. Met...