An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer

• Published in: Journal of chemical technology and biotechnology (1986) Vol. 90; no. 7; pp. 1222 - 1229
• Main Authors: Goodall, Stephen, Howard, Christopher B., Jones, Martina L., Munro, Trent, Jia, Zhongfan, Monteiro, Michael J., Mahler, Stephen
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2015; Wiley Subscription Services, Inc
• Subjects: Antibodies; Binding; Construction; drug delivery; Drug delivery systems; EGFR; Fragments; immunomicelle; immunoparticle; Nanoparticles; PNIPAM; Proteins; scFv; Self assembly

BACKGROUND Decorating nanoparticles with proteins, antibodies and antibody fragments allows highly specific targeting to selected cells for improved delivery of therapeutics and diagnostics. A range of particles have previously been trialled in drug delivery including liposomes, dendrimers, hydrogel...