The Pathogenesis of 3 Neurotropic Flaviviruses in a Mouse Model Depends on the Route of Neuroinvasion After Viremia

• Published in: Journal of neuropathology and experimental neurology Vol. 74; no. 3; pp. 250 - 260
• Main Authors: Nagata, Noriyo, Iwata-Yoshikawa, Naoko, Hayasaka, Daisuke, Sato, Yuko, Kojima, Asato, Kariwa, Hiroaki, Takashima, Ikuo, Takasaki, Tomohiko, Kurane, Ichiro, Sata, Tetsutaro, Hasegawa, Hideki
• Format: Journal Article
• Language: English
• Published: England American Association of Neuropathologists, Inc 01.03.2015; by American Association of Neuropathologists, Inc
• Subjects: Animals; Central Nervous System - pathology; Central Nervous System - virology; Cercopithecus aethiops; Cricetinae; Disease Models, Animal; Encephalitis Viruses, Tick-Borne - isolation & purification; Female; Flavivirus - isolation & purification; Flavivirus Infections - pathology; Mice; Mice, Inbred BALB C; Vero Cells; Viremia - pathology; Encephalitis; Viremia; West Nile virus; Japanese encephalitis virus; Mouse model; Tick-borne encephalitis virus; Flavivirus; Peripheral neuritis

Neurotropic flavivirus infection of humans results in viremia subsequently; in some cases, it causes meningitis encephalomyelitis, although the pathways from viremia to central nervous system (CNS) invasion are uncertain. Here, we intravenously infected BALB/c mice with 3 neurotropic flaviviruses, t...