The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences

Summary The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum, confers hypovirulence‐associated traits...

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Published inMolecular plant pathology Vol. 21; no. 2; pp. 230 - 243
Main Authors Yu, Jisuk, Park, Ju Yeon, Heo, Jeong‐In, Kim, Kook‐Hyung
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2020
John Wiley and Sons Inc
Subjects
Antiviral agents
Antiviral Agents - metabolism
Defense
Deoxyribonucleic acid
DNA
DNA methylation
double-stranded RNA
Fluorescence
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungal Viruses - pathogenicity
Fungi
Fusarium - metabolism
Fusarium - virology
Fusarium graminearum
Fusarium graminearum virus 1
Gene expression
Genes
Genetic transcription
Green fluorescent protein
Health aspects
Infection
Infections
Laboratories
messenger RNA
mutants
Mycelia
mycelium
mycovirus
Open reading frames
ORF2
Original
Pathogenicity
Pathogens
Pigmentation
Proteins
RNA
RNA Interference
RNA viruses
RNA-mediated interference
RNAi
silencing suppressor
Transcription
transcription (genetics)
Virus diseases
Viruses
mycovirus
RNAi
ORF2
silencing suppressor
Fusarium graminearum virus 1
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Abstract Summary The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum, confers hypovirulence‐associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1, which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum. In an FgAGO1‐ or FgDICER2‐promoter/GFP‐reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1‐infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2‐encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICERs and FgAGOs in vitro. These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter‐dependent manner. The ORF2 protein of Fusarium graminearum virus 1 can directly repress the induction of FgDICER2 and FgAGO1 at the transcriptional level to counteract the RNAi defence response of Fusarium graminearum.
AbstractList The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum, confers hypovirulence‐associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1, which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum. In an FgAGO1‐ or FgDICER2‐promoter/GFP‐reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1‐infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2‐encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICERs and FgAGOs in vitro. These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter‐dependent manner.
Summary The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum, confers hypovirulence‐associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1, which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum. In an FgAGO1‐ or FgDICER2‐promoter/GFP‐reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1‐infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2‐encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICERs and FgAGOs in vitro. These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter‐dependent manner. The ORF2 protein of Fusarium graminearum virus 1 can directly repress the induction of FgDICER2 and FgAGO1 at the transcriptional level to counteract the RNAi defence response of Fusarium graminearum.
The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum , confers hypovirulence‐associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1 , which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum . In an FgAGO1 ‐ or FgDICER2 ‐promoter/GFP‐reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1‐infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2‐encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICER s and FgAGO s in vitro . These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter‐dependent manner. The ORF2 protein of Fusarium graminearum virus 1 can directly repress the induction of FgDICER2 and FgAGO1 at the transcriptional level to counteract the RNAi defence response of Fusarium graminearum .
The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double‐stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum , confers hypovirulence‐associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1 , which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum . In an FgAGO1 ‐ or FgDICER2 ‐promoter/GFP‐reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1‐infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2‐encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICER s and FgAGO s in vitro . These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter‐dependent manner.
The filamentous fungus Fusarium graminearum possesses an RNA-interference (RNAi) pathway that acts as a defence response against virus infections and exogenous double-stranded (ds) RNA. Fusarium graminearum virus 1 (FgV1), which infects F. graminearum, confers hypovirulence-associated traits such as reduced mycelial growth, increased pigmentation and reduced pathogenicity. In this study, we found that FgV1 can suppress RNA silencing by interfering with the induction of FgDICER2 and FgAGO1, which are involved in RNAi antiviral defence and the hairpin RNA/RNAi pathway in F. graminearum. In an FgAGO1- or FgDICER2-promoter/GFP-reporter expression assay the green fluorescent protein (GFP) transcript levels were reduced in FgV1-infected transformed mutant strains. By comparing transcription levels of FgDICER2 and FgAGO1 in fungal transformed mutants expressing each open reading frame (ORF) of FgV1 with or without a hairpin RNA construct, we determined that reduction of FgDICER2 and FgAGO1 transcript levels requires only the FgV1 ORF2-encoded protein (pORF2). Moreover, we confirmed that the pORF2 binds to the upstream region of FgDICERs and FgAGOs in vitro. These combined results indicate that the pORF2 of FgV1 counteracts the RNAi defence response of F. graminearum by interfering with the induction of FgDICER2 and FgAGO1 in a promoter-dependent manner.
Audience Academic
Author Heo, Jeong‐In
Kim, Kook‐Hyung
Park, Ju Yeon
Yu, Jisuk
AuthorAffiliation 3 Research Institute of Agriculture and Life Sciences Seoul National University Seoul Korea
2 Department of Agricultural Biotechnology Seoul National University Seoul Korea
1 Plant Genomics and Breeding Institute Seoul National University Seoul Korea
AuthorAffiliation_xml – name: 1 Plant Genomics and Breeding Institute Seoul National University Seoul Korea
– name: 3 Research Institute of Agriculture and Life Sciences Seoul National University Seoul Korea
– name: 2 Department of Agricultural Biotechnology Seoul National University Seoul Korea
Author_xml – sequence: 1
  givenname: Jisuk
  surname: Yu
  fullname: Yu, Jisuk
  organization: Seoul National University
– sequence: 2
  givenname: Ju Yeon
  surname: Park
  fullname: Park, Ju Yeon
  organization: Seoul National University
– sequence: 3
  givenname: Jeong‐In
  surname: Heo
  fullname: Heo, Jeong‐In
  organization: Seoul National University
– sequence: 4
  givenname: Kook‐Hyung
  orcidid: 0000-0001-9066-6903
  surname: Kim
  fullname: Kim, Kook‐Hyung
  email: kookkim@snu.ac.kr
  organization: Seoul National University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31815356$$D View this record in MEDLINE/PubMed
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Copyright 2019 The Authors. published by British Society for Plant Pathology and John Wiley & Sons Ltd
2019 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd.
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DocumentTitleAlternate FgV1 ORF2 functions as VSR to suppress host RNAi
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Issue 2
Keywords mycovirus
RNAi
ORF2
silencing suppressor
Fusarium graminearum virus 1
Language English
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2019 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd.
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Snippet Summary The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and...
The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and...
The filamentous fungus Fusarium graminearum possesses an RNA-interference (RNAi) pathway that acts as a defence response against virus infections and...
The filamentous fungus Fusarium graminearum possesses an RNA-interference (RNAi) pathway that acts as a defence response against virus infections and exogenous...
The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi) pathway that acts as a defence response against virus infections and exogenous...
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SubjectTerms Antiviral agents
Antiviral Agents - metabolism
Defense
Deoxyribonucleic acid
DNA
DNA methylation
double-stranded RNA
Fluorescence
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungal Viruses - pathogenicity
Fungi
Fusarium - metabolism
Fusarium - virology
Fusarium graminearum
Fusarium graminearum virus 1
Gene expression
Genes
Genetic transcription
Green fluorescent protein
Health aspects
Infection
Infections
Laboratories
messenger RNA
mutants
Mycelia
mycelium
mycovirus
Open reading frames
ORF2
Original
Pathogenicity
Pathogens
Pigmentation
Proteins
RNA
RNA Interference
RNA viruses
RNA-mediated interference
RNAi
silencing suppressor
Transcription
transcription (genetics)
Virus diseases
Viruses
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Title The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences
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