Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor‐controlled lipid homeostasis

• Published in: Hepatology (Baltimore, Md.) Vol. 59; no. 5; pp. 1761 - 1771
• Main Authors: Xu, Jiesi, Li, Yuanyuan, Chen, Wei‐Dong, Xu, Yang, Yin, Liya, Ge, Xuemei, Jadhav, Kavita, Adorini, Luciano, Zhang, Yanqiao
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2014
• Subjects: Animals; Carboxylic Ester Hydrolases - physiology; Cholesterol - blood; Fatty Acids - metabolism; Hepatology; Homeostasis; Lipid Metabolism; Lipids; Lipogenesis; Liver - enzymology; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear - physiology; Rodents; Sterol Regulatory Element Binding Protein 1 - physiology; Triglycerides - metabolism

Nonalcoholic fatty liver disease (NAFLD) is one of the major health concerns worldwide. Farnesoid X receptor (FXR) is considered a therapeutic target for treatment of NAFLD. However, the mechanism by which activation of FXR lowers hepatic triglyceride (TG) levels remains unknown. Here we investigate...