Social peers rescue autism-relevant sociability deficits in adolescent mice

• Published in: Autism research Vol. 4; no. 1; p. 17
• Main Authors: Yang, Mu, Perry, Kayla, Weber, Michael D, Katz, Adam M, Crawley, Jacqueline N
• Format: Journal Article
• Language: English
• Published: United States 01.02.2011
• Subjects: Age Factors; Animals; Child; Child Development Disorders, Pervasive - genetics; Child Development Disorders, Pervasive - physiopathology; Child Development Disorders, Pervasive - rehabilitation; Communication; Disease Models, Animal; DNA Mutational Analysis; Genetic Carrier Screening; Genotype; Humans; Mice; Mice, Neurologic Mutants; Peer Group; Phenotype; Social Behavior; Social Environment; Stereotyped Behavior - physiology; Synapses - genetics

Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prom...