Leptin receptor (Ob‐R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV‐infected patients

• Published in: Clinical and experimental immunology Vol. 129; no. 1; pp. 119 - 124
• Main Authors: SÁNCHEZ‐MARGALET, V., MARTÍN‐ROMERO, C., GONZÁLEZ‐YANES, C., GOBERNA, R., RODRÍGUEZ‐BAÑO, J., MUNIAIN, M. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2002; Blackwell; Oxford University Press; Blackwell Science Inc
• Subjects: Adolescent; Adult; Biological and medical sciences; Carrier Proteins - biosynthesis; Carrier Proteins - drug effects; Carrier Proteins - genetics; Carrier Proteins - physiology; cell activation HIV leptin receptor lymphocytes PBMC; Cells, Cultured - metabolism; Child; Concanavalin A - pharmacology; Female; Gene Expression Regulation - drug effects; Hepatitis C - complications; Hepatitis C - immunology; HIV Infections - complications; HIV Infections - immunology; Human viral diseases; Humans; Infectious diseases; Leptin - pharmacology; Leptin - physiology; Lymphocyte Activation - drug effects; Lymphocyte Activation - genetics; Male; Medical sciences; Original; Phosphorylation; Phytohemagglutinins - pharmacology; Protein Isoforms - biosynthesis; Protein Isoforms - drug effects; Protein Isoforms - genetics; Protein Isoforms - physiology; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Leptin; Recombinant Proteins - pharmacology; RNA, Messenger - biosynthesis; Signal Transduction - drug effects; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Immune response; Immunomodulation; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Viral disease; Leptin; Human immunodeficiency virus; Lymphocyte; Biological receptor

SUMMARY Leptin, the Ob gene product, is an adipocyte hormone that centrally regulates weight control. In addition, other effects of leptin in peripheral tissues have been described. Thus, leptin has been found to regulate reproduction, haematopoiesis and immune function. We have found recently that...