Association between genetic polymorphisms involved in the hypoxia‐inducible factor pathway and lung cancer risk: a case–control study in Japan
Aim Hypoxia‐inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and gene...
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Published in | Asia-Pacific journal of clinical oncology Vol. 13; no. 3; pp. 234 - 242 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Wiley Subscription Services, Inc
01.06.2017
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Abstract | Aim
Hypoxia‐inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway.
Methods
This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real‐time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined.
Results
The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant.
Conclusion
HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results. |
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AbstractList | Aim
Hypoxia‐inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway.
Methods
This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real‐time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined.
Results
The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant.
Conclusion
HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results. Aim Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. Methods This case-control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. Results The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30-0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24-0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. Conclusion HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results. AIMHypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway.METHODSThis case-control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined.RESULTSThe AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30-0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24-0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant.CONCLUSIONHIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results. Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. This case-control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30-0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24-0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results. |
Author | Yamamoto, Yuzo Hamada, Naoki Ogata‐Suetsugu, Saiko Kiyohara, Chikako Nakanishi, Yoichi |
Author_xml | – sequence: 1 givenname: Yuzo surname: Yamamoto fullname: Yamamoto, Yuzo organization: Kyushu University – sequence: 2 givenname: Chikako surname: Kiyohara fullname: Kiyohara, Chikako email: chikako@phealth.med.kyushu-u.ac.jp organization: Kyushu University – sequence: 3 givenname: Saiko surname: Ogata‐Suetsugu fullname: Ogata‐Suetsugu, Saiko organization: Kyushu University – sequence: 4 givenname: Naoki surname: Hamada fullname: Hamada, Naoki organization: Kyushu University – sequence: 5 givenname: Yoichi surname: Nakanishi fullname: Nakanishi, Yoichi organization: Kyushu University |
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CitedBy_id | crossref_primary_10_1016_j_clbc_2021_03_012 crossref_primary_10_1016_j_heliyon_2023_e20226 crossref_primary_10_1080_1120009X_2022_2045825 crossref_primary_10_1155_2018_4863757 crossref_primary_10_1097_MD_0000000000020610 crossref_primary_10_1186_s12885_019_6329_2 crossref_primary_10_3892_ijo_2018_4417 crossref_primary_10_3389_fimmu_2023_1267641 crossref_primary_10_1155_2018_9271215 crossref_primary_10_3389_pore_2023_1611444 crossref_primary_10_1097_MD_0000000000034089 |
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References_xml | – volume: 35 start-page: 689 year: 2014 end-page: 94 article-title: Quantitative assessment of the influence of common variations on 6p21 and lung cancer risk publication-title: Tumour Biol – volume: 13 start-page: 4686 year: 2007 end-page: 94 article-title: Nicotine induces hypoxia‐inducible factor‐1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor‐mediated signaling pathways publication-title: Clin Cancer Res – volume: 8 start-page: 56 year: 2008 end-page: 61 article-title: A microenvironmental model of carcinogenesis publication-title: Nat Rev Cancer – volume: 10 start-page: e0134496 year: 2015 article-title: The A allele at rs13419896 of EPAS1 is associated with enhanced expression and poor prognosis for non‐small cell lung cancer publication-title: PLoS One – volume: 159 start-page: 42 year: 2012 end-page: 50 article-title: Association of hypoxia inducible factor‐1alpha polymorphisms with susceptibility to non‐small‐cell lung cancer publication-title: Trans Res – volume: 157 start-page: 411 year: 2000 end-page: 21 article-title: The expression and distribution of the hypoxia‐inducible factors HIF‐1alpha and HIF‐2alpha in normal human tissues, cancers, and tumor‐associated macrophages publication-title: Am J Pathol – volume: 14 start-page: 864 year: 2012 end-page: 9 article-title: Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population publication-title: Asian J Androl – volume: 31 start-page: 1381 year: 2010 end-page: 6 article-title: Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer publication-title: Carcinogenesis – volume: 30 start-page: 1 year: 2013 end-page: 5 article-title: Polymorphism of VEGF‐460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population publication-title: Med Oncol – volume: 36 start-page: 685 year: 1983 end-page: 97 article-title: The relative efficiencies of matched and independent sample designs for case–control studies publication-title: J Chronic Dis – volume: 39 start-page: 338 year: 2008 end-page: 45 article-title: Single nucleotide polymorphisms in the hypoxia‐inducible factor‐1alpha (HIF‐1alpha) gene in human sporadic breast cancer publication-title: Arch Med Res – volume: 16 start-page: 796 year: 2011 end-page: 802 article-title: Hypoxia‐inducible factor‐1alpha polymorphisms are associated with genetic aberrations in lung cancer publication-title: Respirology – volume: 65 start-page: 88 year: 2014 end-page: 94 article-title: Genetic polymorphisms involved in the inflammatory response and lung cancer risk: A case–control study in Japan publication-title: Cytokine – volume: 131 start-page: 2519 year: 2012 end-page: 27 article-title: Nicotinic modulation of therapeutic response in vitro and in vivo publication-title: Int J Cancer – volume: 48 start-page: 20 year: 2014 end-page: 34 article-title: Understanding the links between education and smoking publication-title: Soc Sci Res – volume: 143 start-page: e1S issue: 5 Suppl year: 2013 end-page: 29S article-title: Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence‐based clinical practice guidelines publication-title: Chest – volume: 176 start-page: 2292 year: 2010 end-page: 301 article-title: HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers publication-title: Am J Pathol – volume: 12 start-page: 1033 year: 2004 end-page: 7 article-title: Single nucleotide polymorphism in the hypoxia‐inducible factor‐1alpha gene in colorectal carcinoma publication-title: Oncol Rep – volume: 23 start-page: 981 year: 2012 end-page: 9 article-title: The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma publication-title: Ann Oncol – volume: 12 start-page: 9 year: 2012 end-page: 22 article-title: HIF1alpha and HIF2alpha: Sibling rivalry in hypoxic tumour growth and progression publication-title: Nat Rev Cancer – volume: 218 start-page: 182 year: 2009 end-page: 91 article-title: Current smoking‐specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer publication-title: J Pathol – volume: 67 start-page: 563 year: 2007 end-page: 72 article-title: Hypoxia‐inducible factor‐1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression publication-title: Cancer Res – volume: 107 start-page: 14182 year: 2010 end-page: 7 article-title: HIF‐2alpha deletion promotes Kras‐driven lung tumor development publication-title: Proc Natl Acad Sci U S A – volume: 119 start-page: 2160 year: 2009 end-page: 70 article-title: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice publication-title: J Clin Invest – volume: 20 start-page: 575 year: 2005 end-page: 9 article-title: Calculating measures of biological interaction publication-title: Eur J Epidemiol – volume: 127 start-page: 63 year: 2015 end-page: 73 article-title: When does education matter? The protective effect of education for cohorts graduating in bad times publication-title: Soc Sci Med – volume: 119 start-page: 718 year: 2006 end-page: 21 article-title: Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer publication-title: Int J Cancer – volume: 26 start-page: 433 year: 2011 end-page: 8 article-title: Estimating measures of interaction on an additive scale for preventive exposures publication-title: Eur J Epidemiol – volume: 27 start-page: 560 year: 2006 end-page: 7 article-title: Polymorphisms of DNA repair genes and risk of non‐small cell lung cancer publication-title: Carcinogenesis – volume: 126 start-page: 1131 year: 1991 end-page: 4 article-title: Cigarette smoking decreases tissue oxygen publication-title: Arch Surg – volume: 153 start-page: 122 year: 2004 end-page: 6 article-title: Polymorphisms in the hypoxia inducible factor‐1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype publication-title: Cancer Genet Cytogenet – volume: 85 start-page: 881 year: 2001 end-page: 90 article-title: Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non‐small cell lung cancer to angiogenic/molecular profile of tumours and survival publication-title: Br J Cancer – volume: 20 start-page: 2520 year: 2014 end-page: 6 article-title: rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: A meta‐analysis publication-title: Med Sci Monit – volume: 14 start-page: 1 year: 2014 end-page: 17 article-title: Association between HIF‐1alpha C1772T/G1790A polymorphisms and cancer susceptibility: An updated systematic review and meta‐analysis based on 40 case–control studies publication-title: BMC Cancer – volume: 48 start-page: 563 year: 2009 end-page: 9 article-title: Common polymorphisms in the vascular endothelial growth factor gene and colorectal cancer development, prognosis, and survival publication-title: Mol Carcinog – volume: 10 start-page: 2233 year: 2011 end-page: 4 article-title: Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization publication-title: Cell Cycle – volume: 66 start-page: 314 year: 2009 end-page: 8 article-title: Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non‐small cell lung cancer patients: Relation to prognosis publication-title: Lung Cancer – volume: 124 start-page: 11 year: 2011 end-page: 8 article-title: Correlations of hypoxia‐inducible factor‐1alpha/hypoxia‐inducible factor‐2alpha expression with angiogenesis factors expression and prognosis in non‐small cell lung cancer publication-title: Chin Med J – start-page: 198 year: 2012 end-page: 210 – volume: 70 start-page: 1469 year: 2006 end-page: 80 article-title: Hypoxia‐inducible factor‐1 (HIF‐1) publication-title: Mol Pharmacol – volume: 123 start-page: 3664 year: 2013 end-page: 71 article-title: HIF‐1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations publication-title: J Clin Invest – volume: 3 start-page: 401 year: 2003 end-page: 10 article-title: Tumorigenesis and the angiogenic switch publication-title: Nat Rev Cancer – volume: 31 start-page: 1 year: 2014 end-page: 9 article-title: Polymorphisms of HIF1A gene are associated with prognosis of early stage non‐small‐cell lung cancer patients after surgery publication-title: Med Oncol |
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Hypoxia‐inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may... Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect... Aim Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may... AIMHypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may... |
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SubjectTerms | Aged Cigarette smoking Female Health risk assessment Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a hypoxia‐inducible factor interaction Japan Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Middle Aged Occupational hazards Polymerase chain reaction polymorphism Polymorphism, Genetic - genetics Smoking Tumor cells Vascular endothelial growth factor |
Title | Association between genetic polymorphisms involved in the hypoxia‐inducible factor pathway and lung cancer risk: a case–control study in Japan |
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