Neurobehavioral hazard identification and characterization for caffeine

• Published in: Regulatory toxicology and pharmacology Vol. 74; pp. 81 - 92
• Main Authors: Turnbull, Duncan, Rodricks, Joseph V., Mariano, Gregory F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2016
• Subjects: Aggression - drug effects; Animals; Anxiety; Anxiety - chemically induced; Anxiety - physiopathology; Anxiety - psychology; Caffeine; Caffeine - adverse effects; Caffeine - pharmacokinetics; Central Nervous System - drug effects; Central Nervous System - physiopathology; Central Nervous System Stimulants - adverse effects; Central Nervous System Stimulants - pharmacokinetics; Dose-Response Relationship, Drug; Humans; Neurotoxicity Syndromes - diagnosis; Neurotoxicity Syndromes - etiology; Neurotoxicity Syndromes - physiopathology; Neurotoxicity Syndromes - psychology; Recommended Dietary Allowances; Risk Assessment; Risk-Taking; Sleep - drug effects; Sleep disturbance; Sleep Wake Disorders - chemically induced; Sleep Wake Disorders - physiopathology; Sleep Wake Disorders - psychology; Substance Withdrawal Syndrome - etiology; Substance Withdrawal Syndrome - physiopathology; Substance Withdrawal Syndrome - psychology; Sleep disturbance; Anxiety; Risk-taking; Caffeine

This report evaluates the scientific literature on caffeine with respect to potential central nervous system (CNS) effects, specifically effects on sleep, anxiety, and aggression/risk-taking. Caffeine has been the subject of more scientific safety studies than any other food ingredient. It is import...