Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

• Published in: Cellular & molecular immunology Vol. 12; no. 4; pp. 435 - 443
• Main Authors: Liang, Hua, Duan, Zhaojun, Li, Dan, Li, Dongliang, Wang, Zheng, Ren, Li, Shen, Tao, Shao, Yiming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2015; Nature Publishing Group
• Subjects: Adult; Antibodies; Antigens, CD - blood; Antigens, CD - immunology; Antigens, Differentiation, Myelomonocytic - blood; Antigens, Differentiation, Myelomonocytic - immunology; Biomedical and Life Sciences; Biomedicine; Blood Platelets - immunology; Blood Platelets - metabolism; CD163 antigen; CD4 antigen; Cell activation; HIV; HIV Infections - blood; HIV Infections - immunology; HIV-1 - immunology; HIV-1 - metabolism; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune response; Immunology; Infections; Medical Microbiology; Membrane Glycoproteins - blood; Membrane Glycoproteins - immunology; Microbiology; Monocytes; Monocytes - immunology; Monocytes - metabolism; P-selectin; P-selectin glycoprotein ligand 1; Plasma levels; Platelet Aggregation - immunology; Platelets; Receptors, Cell Surface - blood; Receptors, Cell Surface - immunology; research-article; Thromboembolism; Vaccine; Viremia; Viremia - blood; Viremia - immunology; HIV-1; monocytes; platelets; immune activation; sCD163

Increased levels of monocyte–platelet aggregates (MPAs) are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. T...