Indirect Calorimetry-Based Novel Approach for Evaluating Metabolic Flexibility and Its Association with Circulating Metabolic Markers in Middle-Aged Subjects

• Published in: Nutrients Vol. 16; no. 4; p. 525
• Main Authors: Murru, Elisabetta, Manca, Claudia, Carta, Gianfranca, Ruggiu, Michele, Solinas, Roberto, Montisci, Roberta, Hodson, Leanne, Dearlove, David, Mollica, Maria Pina, Tocco, Filippo, Banni, Sebastiano
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.02.2024; MDPI
• Subjects: Aging; beta oxidation; biomarkers; Body fat; Body mass index; calorimeters; Calorimetry; Calorimetry, Indirect; carbohydrates; Cardiac stress tests; Diabetes; docosahexaenoic acid; Docosahexaenoic Acids; Eicosapentaenoic Acid; Endocannabinoids; Energy; Enzymes; Ethylenediaminetetraacetic acid; Exercise; exercise test; Fasting; Female; Flexibility; gas exchange; Glucose; Homeostasis; Humans; Instrument industry; Insulin resistance; lean body mass; Lipids; Male; Metabolic syndrome; Middle age; Middle Aged; Musculoskeletal system; Oxidation; Oxidation-Reduction; peroxisome proliferator-activated receptors; Physical fitness; Physiology; PPAR alpha; Resveratrol; Risk factors; Type 2 diabetes; Womens health; Workloads; United States; 2-arachidonoylglycerol (2-AG); metabolic flexibility; endocannabinoid system; peroxisome proliferator-activated receptor α (PPARα); N-oleoylethanolamine (OEA); indirect calorimetry

We propose a novel method for assessing metabolic flexibility (MF) through indirect calorimetry. A total of twenty healthy volunteers (10 females; 10 males) aged 45–65 were categorized into a Low-Intensity activity group (LI, 0–1 session of 1 h per week) and a High-Intensity activity group (HI, 5–6...