Consumption of both low and high (−)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: A randomized controlled trial

• Published in: Archives of biochemistry and biophysics Vol. 559; pp. 29 - 37
• Main Authors: Gasper, Amy, Hollands, Wendy, Casgrain, Amelie, Saha, Shikha, Teucher, Birgit, Dainty, Jack R., Venema, Dini P., Hollman, Peter C., Rein, Maarit J., Nelson, Rebecca, Williamson, Gary, Kroon, Paul A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014
• Subjects: adenosine diphosphate; Adult; apples; Ascorbic Acid - blood; aspirin; Biomarkers - blood; black tea; Blood Platelets - drug effects; Blood Platelets - physiology; C-Reactive Protein - metabolism; Catechin - analysis; Catechin - pharmacology; Catechin - urine; Eating; endothelial dysfunction; Endothelin-1 - blood; epicatechin; epinephrine; flavanol-rich cocoa; Flavonoids; Food Handling; food sources; fruit puree; grape juice; green tea catechins; Humans; in-vivo; Lipids - blood; Male; Malus - chemistry; metabolites; Middle Aged; Nitric oxide; Nitric Oxide - metabolism; Platelet reactivity; randomized clinical trials; red wine; reduces blood-pressure; regular ingestion; Young Adult; Platelet reactivity; Flavonoids; Nitric oxide
• ISSN: 0003-9861; 1096-0384; 1096-0384
• DOI: 10.1016/j.abb.2014.05.026

•Apples are a rich dietary source of flavanols.•Apple puree ingestion induces transient decreases in platelet activity.•Apple puree ingestion increases plasma concentrations of nitric oxide metabolites in the short term. We hypothesised that consumption of flavanol-containing apple puree would modul...