Pathogenic differences of cynomolgus macaques after Taï Forest virus infection depend on the viral stock propagation

• Published in: PLoS pathogens Vol. 20; no. 6; p. e1012290
• Main Authors: Fletcher, Paige, Clancy, Chad S, O'Donnell, Kyle L, Doratt, Brianna M, Malherbe, Delphine C, Rhoderick, Joseph F, Feldmann, Friederike, Hanley, Patrick W, Takada, Ayato, Messaoudi, Ilhem, Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2024; Public Library of Science (PLoS)
• Subjects: Alphavirus Infections - pathology; Alphavirus Infections - virology; Animal models; Animal models in research; Animals; Biology and life sciences; Cytokines; Development and progression; Disease Models, Animal; Enzymes; Epidemics; Genomic analysis; Glycoproteins; Health aspects; Humans; Immunoglobulin G; Infections; Inoculation; Kra; Liver; Macaca fascicularis; Medicine and Health Sciences; Mice; Mice, Knockout; Necropsy; Pathogenicity; Pathogens; Pest outbreaks; Phenotypes; R&D; Receptor, Interferon alpha-beta - genetics; Research & development; Research and Analysis Methods; RNA polymerase; RNA virus infections; RNA viruses; Survival; Thrombocytopenia; Tissue analysis; Viremia; Virus Replication; Viruses; United States; West Africa

Taï Forest virus (TAFV) is a negative-sense RNA virus in the Filoviridae family. TAFV has caused only a single human infection, but several disease outbreaks in chimpanzees have been linked to this virus. Limited research has been done on this human-pathogenic virus. We sought to establish an animal...