C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

• Published in: Molecular cell Vol. 75; no. 6; pp. 1299 - 1314.e6
• Main Authors: Bai, Yongtai, Wang, Weibin, Li, Siyu, Zhan, Jun, Li, Hanxiao, Zhao, Meimei, Zhou, Xiao Albert, Li, Shiwei, Li, Xiaoman, Huo, Yanfei, Shen, Qinjian, Zhou, Mei, Zhang, Hongquan, Luo, Jianyuan, Sung, Patrick, Zhu, Wei-Guo, Xu, Xingzhi, Wang, Jiadong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.09.2019
• Subjects: Acid Anhydride Hydrolases - genetics; Acid Anhydride Hydrolases - metabolism; Animals; breast neoplasms; C1QBP; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; chromatin; DNA; DNA damage; DNA damage repair; DNA double-strand breaks; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; drug therapy; enzyme activity; enzymes; genetic instability; HEK293 Cells; HeLa Cells; Homologous Recombination; Humans; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; MRE11; MRE11 Homologue Protein - genetics; MRE11 Homologue Protein - metabolism; MRN complex; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Protein Stability; remission; resection; Sf9 Cells; Spodoptera; DNA damage repair; MRE11; homologous recombination; DNA double-strand breaks; C1QBP; MRN complex

MRE11 nuclease forms a trimeric complex (MRN) with RAD50 and NBS1 and plays a central role in preventing genomic instability. When DNA double-strand breaks (DSBs) occur, MRN is quickly recruited to the damage site and initiates DNA end resection; accordingly, MRE11 must be tightly regulated to avoid...