Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation

• Published in: Allergy, asthma & immunology research Vol. 13; no. 5; pp. 684 - 696
• Main Authors: Xu, Xu, Li, Jingyun, Zhang, Yuan, Zhang, Luo
• Format: Journal Article
• Language: English
• Published: Seoul Korean Academy of Asthma, Allergy and Clinical Immunology 01.09.2021; The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease; 대한천식알레르기학회
• Subjects: Arachidonic acid; Aspirin; Asthma; Cell differentiation; Cell migration; Chronic obstructive pulmonary disease; Dendritic cells; Deoxyribonucleic acid; Differentiation (biology); DNA; DNA methylation; Epigenetics; Epithelial cells; Epithelium; Etiology; Extracellular signal-regulated kinase; Fatty acids; Genetic diversity; Genome-wide association studies; Genomes; Health services; Histones; Immune system; Inflammation; Inflammatory diseases; Interleukin 13; Interleukins; Janus kinase 2; Kinases; Leukocytes (eosinophilic); Lipoxygenase; Lung diseases; Lymphocytes; Lymphocytes T; Metabolic pathways; Metabolites; Phenotypes; Polyunsaturated fatty acids; Respiratory diseases; Respiratory tract diseases; Review; Transcription factors; Transducers; 내과학

Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory dis...