Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction
This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day...
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Published in | Journal of Korean medical science Vol. 28; no. 12; pp. 1749 - 1755 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
The Korean Academy of Medical Sciences
01.12.2013
대한의학회 |
Subjects | |
Online Access | Get full text |
ISSN | 1011-8934 1598-6357 1598-6357 |
DOI | 10.3346/jkms.2013.28.12.1749 |
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Abstract | This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI. |
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AbstractList | This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n=21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P=0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P=0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI. KCI Citation Count: 3 This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI. This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI.This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI. This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 patients (27.4%) had diabetes. Short-term MACEs, which occurred within 30 days of AMI onset, were observed in 1,364 patients (6.1%). Among the 30-day survivors (n = 21,604), mid-term MACEs, which occurred between 31 and 365 days after AMI onset, were observed in 1,181 patients (5.4%). After adjustment for potential confounders, diabetes was an independent predictor of mid-term MACEs (HR, 1.25; 95% CI, 1.08-1.45; P = 0.002), but not of short-term MACEs (HR: 1.16; 95% CI: 0.93-1.44; P = 0.167). Diabetes is a poor prognostic factor for mid-term clinical outcomes but not for short-term outcomes in AMI patients. Careful monitoring and intensive care should be considered in diabetic patients, especially following the acute stage of AMI. |
Author | Cho, Goo-Yeong Cho, Young-Seok Ahn, Youngkeun Kim, Ju Han Chae, In-Ho Yoon, Chang-Hwan Youn, Tae-Jin Kim, Hack-Lyoung Kim, Hyo-Soo Jeong, Myung Ho Cho, Myeong-Chan Kim, Young-Jo Kang, Si-Hyuck Choi, Dong-Ju Chae, Shung-Chull |
AuthorAffiliation | 4 Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea 5 Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea 6 Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea 7 Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea 1 Department of Internal Medicine, Cardiovascular Center, Seoul National University Boramae Medical Center, Seoul, Korea 3 Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea 2 Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea |
AuthorAffiliation_xml | – name: 2 Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea – name: 7 Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea – name: 1 Department of Internal Medicine, Cardiovascular Center, Seoul National University Boramae Medical Center, Seoul, Korea – name: 3 Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – name: 5 Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea – name: 6 Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea – name: 4 Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea |
Author_xml | – sequence: 1 givenname: Hack-Lyoung surname: Kim fullname: Kim, Hack-Lyoung organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Boramae Medical Center, Seoul, Korea – sequence: 2 givenname: Si-Hyuck surname: Kang fullname: Kang, Si-Hyuck organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea – sequence: 3 givenname: Chang-Hwan surname: Yoon fullname: Yoon, Chang-Hwan organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 4 givenname: Young-Seok surname: Cho fullname: Cho, Young-Seok organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 5 givenname: Tae-Jin surname: Youn fullname: Youn, Tae-Jin organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 6 givenname: Goo-Yeong surname: Cho fullname: Cho, Goo-Yeong organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 7 givenname: In-Ho surname: Chae fullname: Chae, In-Ho organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 8 givenname: Hyo-Soo surname: Kim fullname: Kim, Hyo-Soo organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea – sequence: 9 givenname: Shung-Chull surname: Chae fullname: Chae, Shung-Chull organization: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea – sequence: 10 givenname: Myeong-Chan surname: Cho fullname: Cho, Myeong-Chan organization: Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea – sequence: 11 givenname: Young-Jo surname: Kim fullname: Kim, Young-Jo organization: Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea – sequence: 12 givenname: Ju Han surname: Kim fullname: Kim, Ju Han organization: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 13 givenname: Youngkeun surname: Ahn fullname: Ahn, Youngkeun organization: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 14 givenname: Myung Ho orcidid: 0000-0003-4173-1494 surname: Jeong fullname: Jeong, Myung Ho organization: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 15 givenname: Dong-Ju surname: Choi fullname: Choi, Dong-Ju organization: Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea |
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CitedBy_id | crossref_primary_10_1016_j_amjcard_2014_08_038 crossref_primary_10_3904_kjim_2014_29_6_703 crossref_primary_10_1016_j_ijcard_2016_04_182 crossref_primary_10_5551_jat_44818 crossref_primary_10_1016_j_crvasa_2015_11_001 crossref_primary_10_1371_journal_pone_0212398 crossref_primary_10_7717_peerj_6804 crossref_primary_10_2337_dc19_0047 |
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Keywords | Diabetes Mellitus Myocardial Infarction Prognosis |
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SubjectTerms | Acute Disease Aged Cardiovascular Diseases - etiology Cohort Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diagnosis, Differential Female Humans Incidence Male Middle Aged Myocardial Infarction - diagnosis Myocardial Infarction - epidemiology Myocardial Infarction - mortality Original Prognosis Proportional Hazards Models Registries Survival Analysis Time Factors 의학일반 |
Title | Differential Prognostic Impacts of Diabetes over Time Course after Acute Myocardial Infarction |
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