A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

• Published in: Science translational medicine Vol. 7; no. 287; p. 287ra71
• Main Authors: Sweeney, Timothy E, Shidham, Aaditya, Wong, Hector R, Khatri, Purvesh
• Format: Journal Article
• Language: English
• Published: United States 13.05.2015
• Subjects: Cohort Studies; Humans; Inflammation - complications; Inflammation - genetics; Principal Component Analysis; Sepsis - complications; Sepsis - genetics
• ISSN: 1946-6242
• DOI: 10.1126/scitranslmed.aaa5993

Although several dozen studies of gene expression in sepsis have been published, distinguishing sepsis from a sterile systemic inflammatory response syndrome (SIRS) is still largely up to clinical suspicion. We hypothesized that a multicohort analysis of the publicly available sepsis gene expression...