Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks

• Published in: International Journal of Molecular Sciences Vol. 20; no. 24; p. 6348
• Main Authors: Guo, Nancy Lan, Poh, Tuang Yeow, Pirela, Sandra, Farcas, Mariana T., Chotirmall, Sanjay H., Tham, Wai Kin, Adav, Sunil S., Ye, Qing, Wei, Yongyue, Shen, Sipeng, Christiani, David C., Ng, Kee Woei, Thomas, Treye, Qian, Yong, Demokritou, Philip
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.12.2019; MDPI
• Subjects: Air Pollutants; Air Pollutants - analysis; Animals; Biomarkers; Cardiovascular disease; Cell division; Diabetes; Disease; Disease - genetics; Gene expression; inhalation; Inhalation Exposure; Inhalation Exposure - adverse effects; Integrated approach; Laser printers; Lipidomics; Lung; Lung - metabolism; Male; Medicine [Science]; Metabolism; metabolomics; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Nanoparticles; Nanoparticles - adverse effects; Nanotechnology; nanotoxicity; Printer Emitted Nanoparticles; Printing; Rats, Sprague-Dawley; Risk Factors; RNA, Messenger; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Science::Medicine; Serum; Serum - metabolism; Surveillance; Toxicology; Transcriptome; Transcriptome - genetics; transcriptomics; inhalation; nanotoxicity; metabolomics; biomarkers; printer emitted nanoparticles; transcriptomics; lipidomics

Laser printer-emitted nanoparticles (PEPs) generated from toners during printing represent one of the most common types of life cycle released particulate matter from nano-enabled products. Toxicological assessment of PEPs is therefore important for occupational and consumer health protection. Our g...