Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT

• Published in: Cell reports (Cambridge) Vol. 43; no. 3; p. 113881
• Main Authors: Bareja, Akshay, Lee, David E., Ho, Tricia, Waitt, Greg, McKay, Lauren H., Hannou, Sarah A., Orenduff, Melissa C., McGreevy, Kristen M., Binder, Alexandra, Ryan, Calen P., Soderblom, Erik J., Belsky, Daniel W., Ferrucci, Luigi, Das, Jayanta Kumar, Banskota, Nirad, Kraus, Virginia B., Huebner, Janet L., Kraus, William E., Huffman, Kim M., Baht, Gurpreet S., Horvath, Steve, Parmer, Robert J., Miles, Lindsey A., White, James P.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 26.03.2024; Elsevier
• Subjects: CALERIE; caloric restriction; CP: Metabolism; CP: Stem cell research; liver; MetRS; muscle; PAI-1; plasminogen; satellite cell; secretome; stem cell; plasminogen; MetRS; caloric restriction; satellite cell; CP: Stem cell research; stem cell; liver; CP: Metabolism; muscle; PAI-1; CALERIE; secretome

An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274G (MetRS) transgenic mouse to identify liver...