The Roles of Epigenetic Regulation and the Tumor Microenvironment in the Mechanism of Resistance to Systemic Therapy in Hepatocellular Carcinoma - Oura, Kyoko; Morishita, Asahiro; Hamaya, Sae; Fujita, Koji; Masaki, Tsutomu (International Journal of Molecular Sciences, 2023)
Keywords: Cancer therapies; Carcinoma, Hepatocellular; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Chemoembolization, Therapeutic; Cyclin-dependent kinases; DNA methylation; Enzymes; Epigenesis, Genetic; Epigenetics; Gene amplification; Gene expression; Genomes; Hepatitis C; Humans; Immune checkpoint inhibitors; Inhibitor drugs; Kinases; Liver cancer; Liver cirrhosis; Liver Neoplasms; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Medical prognosis; Mutation; Proteins; Review; Targeted cancer therapy; Transcription factors; Tumor Microenvironment; Tumor Microenvironment - genetics; immune checkpoint inhibitor; lenvatinib; sorafenib; tyrosine kinase; molecular target agent; drug resistance; regorafenib; tumor microenvironment; systemic therapy; hepatocellular carcinoma