Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients

• Published in: Environmental science and pollution research international Vol. 29; no. 57; pp. 85569 - 85573
• Main Authors: Moulana, Zahra, Bagherzadeh, Mojgan, Mirzakhani, Mohammad, Rostami, Ali, Mohammadnia-Afrouzi, Mousa, Shahbazi, Mehdi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Acute phase proteins; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; blood serum; C-Reactive Protein - analysis; complement; Complement activation; Coronavirus - metabolism; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - genetics; COVID-19 - metabolism; COVID-19 infection; disease severity; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Enzyme-linked immunosorbent assay; Ficolins; Humans; lectins; Novel Corona Virus (COVID-19) in Environmental Engineering; Novel Corona Virus (COVID-19) in Environmental Engineering Perspective; Pattern recognition; Pattern recognition receptors; Pentraxins; Serum Amyloid P-Component - analysis; Serum Amyloid P-Component - metabolism; Serum levels; Viral diseases; Waste Water Technology; Water Management; Water Pollution Control; COVID-19; Ficolin; Coronavirus; Pentraxin 3; Pattern recognition receptors
• ISSN: 0944-1344; 1614-7499; 1614-7499
• DOI: 10.1007/s11356-021-15183-9

Pentraxin 3 (PTX3) and ficolin are the plasma phase of pattern recognition receptors (PRRs) and can activate complement through classical and lectin pathways, respectively, which may contribute to disease severity. This study aimed to investigate the association between PTX3 and ficolin with disease severity in patients with coronavirus disease-2019 (COVID-19). Seventy-three COVID-19 patients and 25 healthy controls were enrolled in this study. The participants were divided into three groups as follows: 14 patients as the intensive care unit (ICU) group, 59 patients as the non-ICU group, and 25 subjects as the healthy control group. The serum levels of PTX3 and ficolin were measured by enzyme-linked immunosorbent assay (ELISA) kits. Patients in ICU and non-ICU groups had significantly higher levels of PTX3 compared to the healthy control group ( p = 0.0002 and p = 0.0072, respectively). Patients in the ICU group also had an increased amount of PTX3 (1957 ± 1769 pg/ml) compared to non-ICU patients (1220 ± 1784 pg/ml). However, this difference was not significant. On the other hand, serum levels of ficolin were not different among the three groups. PTX3, as an acute phase protein, may contribute to disease severity. Its probable inflammatory role could result from the high activation of the complement system. On the other hand, it could be suggested that ficolin has no crucial role in the disease severity of COVID-19 patients.