Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors

• Published in: Frontiers in neuroscience Vol. 13; p. 740
• Main Authors: Lazarus, Michael, Oishi, Yo, Bjorness, Theresa E., Greene, Robert W.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 17.07.2019; Frontiers Media S.A
• Subjects: A1 receptor; A2A receptor; Adenosine; Adenosine A2A receptors; Arousal; Channel gating; Encephalitis; Homeostasis; Mammals; Nervous system; Neurons; Neuroscience; Neurosciences; Peptides; Receptor mechanisms; Sleep and wakefulness; Sleep deprivation; sleep homeostasis; slow-wave activity; slow-wave sleep; United States > US

Roughly one-third of the human lifetime is spent in sleep, yet the reason for sleep remains unclear. Understanding the physiologic function of sleep is crucial toward establishing optimal health. Several proposed concepts address different aspects of sleep physiology, including humoral and circuit-b...