Mercury's neurotoxicity is characterized by its disruption of selenium biochemistry

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 11; pp. 2405 - 2416
• Main Authors: Ralston, Nicholas V.C., Raymond, Laura J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: biochemical mechanisms; Brain; Lewis bases; Mercury; methylmercury compounds; neurotoxicity; nutrient deficiencies; protective effect; Selenium; Selenoproteins; sulfur; Toxicity; toxicology; Ser; Brain; RSe; Toxicity; SELENOF; SeMet; SELENOK; SeO3; SeO42; Selenium; Cys; CH3HgCH3; CH3Hg; SEPHS2; Hg+ or Hg2; GPX4; TXNRD2; RSH; TXNRD1; DIO1; DIO; ApoER2; Hg0; Sec; LAT1; SELENON; SELENOM; SELENOP; SELENOW; HSe; Selenoproteins; SeO32; Met; Mercury; MSRB1

Methylmercury (CH3Hg+) toxicity is characterized by challenging conundrums: 1) “selenium (Se)-protective” effects, 2) undefined biochemical mechanism/s of toxicity, 3) brain-specific oxidative damage, 4) fetal vulnerability, and 5) its latency effect. The “protective effects of Se” against CH3Hg+ to...