Carrot-Derived Rhamnogalacturonan-I Consistently Increases the Microbial Production of Health-Promoting Indole-3-Propionic Acid Ex Vivo

• Published in: Metabolites Vol. 14; no. 12; p. 722
• Main Authors: Mercenier, Annick, Vu, Lam Dai, Poppe, Jonas, Albers, Ruud, McKay, Sue, Van den Abbeele, Pieter
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Amino acids; Analysis; Bifidobacterium longum; Carbohydrates; carrot rhamnogalacturonan-I (cRG-I); Correlation analysis; dietary fiber; Digestive system; Fatty acids; Feces; Fermentation; Gastrointestinal tract; Health maintenance organizations; indole-3-propionic acid; Indoles; Intestinal microflora; Lactic acid; Metabolism; Metabolites; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); prebiotic; Prebiotics; Propionic acid; Quality control; Rhamnogalacturonan; Statistical analysis; Statistics; Tryptophan; tryptophan metabolism; Type 2 diabetes; carrot rhamnogalacturonan-I (cRG-I); tryptophan metabolism; Bifidobacterium longum; indole-3-propionic acid; prebiotic; dietary fiber; ex vivo

Background: Using dietary interventions to steer the metabolic output of the gut microbiota towards specific health-promoting metabolites is often challenging due to interpersonal variation in treatment responses. Methods: In this study, we combined the ex vivo SIFR® (Systemic Intestinal Fermentatio...