Exosomal Aβ-Binding Proteins Identified by "In Silico" Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 3933
• Main Authors: Soares Martins, Tânia, Marçalo, Rui, Ferreira, Maria, Vaz, Margarida, Silva, Raquel M, Martins Rosa, Ilka, Vogelgsang, Jonathan, Wiltfang, Jens, da Cruz E Silva, Odete A B, Henriques, Ana Gabriela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2021; MDPI
• Subjects: Abeta binding proteins; Alzheimer Disease - blood; Alzheimer's disease; Amyloid beta-Peptides - blood; Amyloidogenesis; biomarker; Biomarkers; Biomarkers - blood; Brain research; Cerebrospinal fluid; Chemokines; Clinical trials; Computer Simulation; Cytokines; Databases, Protein; Dementia disorders; diagnosis; Exosomes; Exosomes - metabolism; Female; Gelsolin; Humans; Inflammation; Male; Metabolism; Parkinson's disease; Plasma; Proteins; Proteomes; Quality of life; diagnosis; Alzheimer’s disease; biomarker; exosomes; Abeta binding proteins

The potential of exosomes as biomarker resources for diagnostics and even for therapeutics has intensified research in the field, including in the context of Alzheimer´s disease (AD). The search for disease biomarkers in peripheral biofluids is advancing mainly due to the easy access it offers. In t...