Improvement of a commercial foot-and-mouth disease vaccine by supplement of Quil A

• Published in: Vaccine Vol. 25; no. 25; pp. 4795 - 4800
• Main Authors: Xiao, Chenwen, Rajput, Zahid Iqbal, Hu, Songhua
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.06.2007; Elsevier; Elsevier Limited
• Subjects: Adjuvant; Adjuvants, Immunologic - pharmacology; Allergy and Immunology; Animal diseases; Animals; Antibodies, Viral - analysis; Antibodies, Viral - biosynthesis; Antigens; Applied microbiology; Biological and medical sciences; Experiments; Female; Foot & mouth disease; Foot-and-mouth disease; Foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - immunology; Fundamental and applied biological sciences. Psychology; Hemagglutination Tests; Immune system; Immunization; Immunoglobulin G - immunology; Infections; Mice; Mice, Inbred ICR; Microbiology; Mineral oil; Mineral oils; Ovalbumin - immunology; Quil A; Quillaja Saponins; Saponins - pharmacology; Swine; Synergistic effect; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral Vaccines - immunology; China; Quil A; Foot-and-mouth disease; Adjuvant; Mineral oil; Vaccine; Infection; Foot and mouth disease; Viral disease; Immunological adjuvant; Veterinary

Abstract In model animal experiment A, ICR mice were immunized with ovalbumin (OVA) adjuvanted with Quil A or mineral oil or their combination (Quil A + oil). In model animal experiment B, ICR mice were immunized with foot-and-mouth disease virus (FMDV) antigens or with a commercially available oil...