25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens

• Published in: Antioxidants Vol. 13; no. 11; p. 1426
• Main Authors: Chiang, Shih-Kai, Sin, Mei-Ying, Lin, Jun-Wen, Siregar, Maraddin, Valdez, Gilmour, Chen, Yu-Hui, Chung, Thau Kiong, Walzem, Rosemary L., Chang, Lin-Chu, Chen, Shuen-Ei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Alfacalcidol; Bioenergetics; Birds; Blood pressure; Body composition; Calcifediol; Cardiomyopathy; Cardiovascular disease; Care and treatment; Cell activation; Cell survival; Cell viability; Chromatography; Dehydrogenases; Electron transport chain; Fatty acids; Feeds; Glucose transport; Health aspects; Heart; Heart failure; Hematocrit; Heme; hens; Homeostasis; Hypertension; Hypertrophy; Kinases; metabolic adaption; Metabolism; Mitochondria; Necropsy; Obesity; Oxidation; Oxidation-reduction reaction; Pathogenesis; Protein structure; Protein turnover; Pulmonary arteries; Pyruvic acid; redox homeostasis; Respiration; Tricarboxylic acid cycle; Vitamin D; Taiwan; United Kingdom > UK; United States > US; India; heart failure; hens; metabolic adaption; redox homeostasis; mitochondria; vitamin D

Broiler breeder hens allowed ad libitum (Ad) feed intake developed obesity and cardiac pathogenesis and thereby were susceptible to sudden death. A supplement of 69 µg 25-hydroxycholecalciferol (25-OH-D3)/kg feed rescued the livability of feed-restricted (R) and Ad-hens (mortality; 6.7% vs. 8.9% and...