Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phen...

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Published inEpigenomics Vol. 15; no. 1; pp. 39 - 52
Main Authors Fragoso-Bargas, Nicolas, Page, Christian M, Joubert, Bonnie R, London, Stephanie J, Lee-Ødegård, Sindre, Opsahl, Julia O, Sletner, Line, Jenum, Anne K, Qvigstad, Elisabeth, Prasad, Rashmi B, Moen, Gunn-Helen, Birkeland, Kåre I, Sommer, Christine
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.01.2023
Subjects
Basic Medicine
DNA Methylation
Epigenesis, Genetic
epigenetic epidemiology
epigenetics
Epigenome
EPIPREG
EWAS
Fetal Blood - metabolism
folate
Folic Acid - metabolism
Genome-Wide Association Study - methods
Leukocytes
Medical and Health Sciences
Medical Genetics
Medicin och hälsovetenskap
Medicinsk genetik
Medicinska och farmaceutiska grundvetenskaper
MoBa
pregnancy
epigenetic epidemiology
folate
EWAS
MoBa
pregnancy
DNA methylation
EPIPREG
epigenetics
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Abstract To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. cg19888088 (cross-ancestry) in , cg01952260 (Europeans) and cg07077240 (South Asians) in were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in . The findings were not replicated and were not significant in cord blood. This research article identified CpG sites associated with serum folate levels in maternal peripheral blood leukocytes. The findings provide new insights about the epigenomic component of serum folate levels.
AbstractList This research article identified CpG sites associated with serum folate levels in maternal peripheral blood leukocytes. The findings provide new insights about the epigenomic component of serum folate levels.
To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. cg19888088 (cross-ancestry) in , cg01952260 (Europeans) and cg07077240 (South Asians) in were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in . The findings were not replicated and were not significant in cord blood. This research article identified CpG sites associated with serum folate levels in maternal peripheral blood leukocytes. The findings provide new insights about the epigenomic component of serum folate levels.
Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.
To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. cg19888088 (cross-ancestry) in , cg01952260 (Europeans) and cg07077240 (South Asians) in were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in . The findings were not replicated and were not significant in cord blood.
Author Prasad, Rashmi B
Moen, Gunn-Helen
Lee-Ødegård, Sindre
Opsahl, Julia O
Fragoso-Bargas, Nicolas
Sletner, Line
Page, Christian M
London, Stephanie J
Qvigstad, Elisabeth
Jenum, Anne K
Birkeland, Kåre I
Joubert, Bonnie R
Sommer, Christine
AuthorAffiliation 2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318, Oslo, Norway
10Institute for Molecular Medicine Finland FIMM, Helsinki University, 00014, Helsinki, Finland
1Department of Endocrinology, Morbid Obesity & Preventive Medicine, Oslo University Hospital, 0424, Oslo, Norway
3Centre for Fertility & Health, Norwegian Institute of Public Health, 0403, Oslo, Norway
11Institute of Molecular Biosciences, The University of Queensland, St Lucia QLD 4072, Australia
9Lund University Diabetes Centre, 214 28, Malmö, Sweden
13The Frazer Institute, The University of Queensland, 4102, Woolloongabba, Australia
14Population Health Sciences, Bristol Medical School, University of Bristol, BS8 1QU, Bristol, United Kingdom
4Department of Mathematics, Faculty of Mathematics & Natural Sciences, University of Oslo, 0315, Oslo, Norway
5Department of Health & Human Services, Population Health Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 
AuthorAffiliation_xml – name: 10Institute for Molecular Medicine Finland FIMM, Helsinki University, 00014, Helsinki, Finland
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– name: 5Department of Health & Human Services, Population Health Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
– name: 14Population Health Sciences, Bristol Medical School, University of Bristol, BS8 1QU, Bristol, United Kingdom
– name: 8Department of General Practice, Institute of Health & Society, University of Oslo, 0318, Oslo, Norway
– name: 13The Frazer Institute, The University of Queensland, 4102, Woolloongabba, Australia
– name: 6Department of Health & Human Services, Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
– name: 7Department of Pediatric & Adolescents Medicine, Akershus University Hospital, 1478, Lørenskog, Norway
– name: 11Institute of Molecular Biosciences, The University of Queensland, St Lucia QLD 4072, Australia
– name: 12Department of Public Health & Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science & Technology, 7491, Trondheim, Norway
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  orcidid: 0000-0002-4400-6741
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  surname: Sommer
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  organization: Department of Endocrinology, Morbid Obesity & Preventive Medicine, Oslo University Hospital, 0424, Oslo, Norway
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Keywords epigenetic epidemiology
folate
EWAS
MoBa
pregnancy
DNA methylation
EPIPREG
epigenetics
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Snippet To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Cross-ancestry (Europeans = 302, South Asians = 161) and...
Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and...
This research article identified CpG sites associated with serum folate levels in maternal peripheral blood leukocytes. The findings provide new insights about...
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StartPage 39
SubjectTerms Basic Medicine
DNA Methylation
Epigenesis, Genetic
epigenetic epidemiology
epigenetics
Epigenome
EPIPREG
EWAS
Fetal Blood - metabolism
folate
Folic Acid - metabolism
Genome-Wide Association Study - methods
Leukocytes
Medical and Health Sciences
Medical Genetics
Medicin och hälsovetenskap
Medicinsk genetik
Medicinska och farmaceutiska grundvetenskaper
MoBa
pregnancy
Title Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes
URI http://dx.doi.org/10.2217/epi-2022-0427
https://www.ncbi.nlm.nih.gov/pubmed/36974632
https://search.proquest.com/docview/2792905877
https://pubmed.ncbi.nlm.nih.gov/PMC10072132
https://lup.lub.lu.se/record/94b87faf-6689-473d-9f06-12446109ea6e
Volume 15
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