Prenatal lead exposure impacts cross-hemispheric and long-range connectivity in the human fetal brain

• Published in: NeuroImage (Orlando, Fla.) Vol. 191; pp. 186 - 192
• Main Authors: Thomason, Moriah E., Hect, Jasmine L., Rauh, Virginia A., Trentacosta, Christopher, Wheelock, Muriah D., Eggebrecht, Adam T., Espinoza-Heredia, Claudia, Burt, S. Alexandra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019; Elsevier Limited
• Subjects: Age; Animal cognition; Brain; Brain - drug effects; Brain - pathology; Cognitive ability; Connectivity; Consent; Cortex (cingulate); Female; Fetal; Fetus; Fetuses; Functional magnetic resonance imaging; Humans; Lead; Lead - adverse effects; Lead poisoning; Lead Poisoning, Nervous System, Childhood - pathology; Magnetic Resonance Imaging - methods; Medical screening; Mothers; MRI; Nervous system; Neural networks; Neural Pathways - drug effects; Neural Pathways - pathology; NMR; Nuclear magnetic resonance; Prefrontal cortex; Pregnancy; Prenatal; Prenatal Diagnosis; Prenatal experience; Prenatal Exposure Delayed Effects - etiology; Prenatal Exposure Delayed Effects - pathology; Resting-state; Detroit Michigan; United States > US; Michigan; Prenatal; Brain; MRI; Lead; Connectivity; Resting-state; Fetal

Lead represents a highly prevalent metal toxicant with potential to alter human biology in lasting ways. A population segment that is particularly vulnerable to the negative consequences of lead exposure is the human fetus, as exposure events occurring before birth are linked to varied and long-rang...