NK cell exhaustion in Wilson’s disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis

• Published in: eLife Vol. 13
• Main Authors: Jin, Yong, Xing, Jiayu, Dai, Chenyu, Jin, Lei, Zhang, Wanying, Tao, Qianqian, Hou, Mei, Li, Ziyi, Yang, Wen, Feng, Qiyu, Wang, Hongyang, Yu, Qingsheng
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 30.12.2024; eLife Sciences Publications, Ltd; eLife Sciences Publications Ltd
• Subjects: Adult; Analysis; B cells; Cholecystitis; Cholecystitis - diagnosis; Cholecystitis - genetics; Cholecystitis - immunology; Fatigue; Female; Hepatolenticular Degeneration - complications; Hepatolenticular Degeneration - genetics; Hepatolenticular Degeneration - immunology; Hepatolenticular Degeneration - pathology; Humans; immune cell dysfunction; Immune System Exhaustion; Immunology and Inflammation; Killer cells; Killer Cells, Natural - immunology; Liver; Liver - immunology; Liver - pathology; Liver diseases; Male; Medical research; Medicine; Medicine, Experimental; metabolic abnormalities; Middle Aged; NK cell exhaustion; Physiological aspects; Prognosis; Retrospective Studies; RNA; RNA sequencing; Sequence Analysis, RNA; Single-Cell Analysis; United States; Massachusetts; China; inflammation; metabolic abnormalities; immune cell dysfunction; medicine; NK cell exhaustion; human; immunology

Metabolic abnormalities associated with liver disease have a significant impact on the risk and prognosis of cholecystitis. However, the underlying mechanism remains to be elucidated. Here, we investigated this issue using Wilson’s disease (WD) as a model, which is a genetic disorder characterized b...