Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway

• Published in: International Journal of Molecular Sciences Vol. 22; no. 8; p. 4056
• Main Authors: Chang, Yuan-Yen, Lee, Yi-Ju, Hsu, Min-Yen, Wang, Meilin, Tsou, Shang-Chun, Chen, Ching-Chung, Lin, Jer-An, Hsiao, Yai-Ping, Lin, Hui-Wen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.04.2021; MDPI
• Subjects: age-related macular degeneration; Animals; Antioxidants; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; bcl-2-Associated X Protein; bcl-2-Associated X Protein - genetics; Caspase 3; Caspase 3 - genetics; Cell Line; Gene Expression Regulation; Gene Expression Regulation - drug effects; Growth factors; human retinal pigment epithelium; Humans; Iodates; Iodates - toxicity; Kinases; Macular Degeneration; Macular Degeneration - drug therapy; Macular Degeneration - genetics; Macular Degeneration - pathology; Mitochondria; Mitochondria - drug effects; mitochondrial membrane potential; Older people; Oxidative stress; Poly(ADP-ribose) Polymerases; Poly(ADP-ribose) Polymerases - genetics; Proteins; quercetin; Quercetin - pharmacology; Reactive Oxygen Species; Reactive Oxygen Species - metabolism; Retina; Retina - drug effects; Retina - pathology; Retinal Diseases; Retinal Diseases - chemically induced; Retinal Diseases - drug therapy; Retinal Diseases - genetics; Retinal Diseases - pathology; Retinal Pigment Epithelium; Retinal Pigment Epithelium - drug effects; Retinal Pigment Epithelium - growth & development; Signal Transduction; Signal Transduction - drug effects; sodium iodate; Software; Statistical analysis; Variance analysis; St Louis Missouri; Ann Arbor Michigan; United States > US; Japan; apoptosis; quercetin; human retinal pigment epithelium; sodium iodate; age-related macular degeneration; mitochondrial membrane potential

Age-related macular degeneration (AMD) leads to gradual central vision loss and is the third leading cause of irreversible blindness worldwide. The underlying mechanisms for this progressive neurodegenerative disease remain unclear and there is currently no preventive treatment for dry AMD. Sodium i...