Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway - Chang, Yuan-Yen; Lee, Yi-Ju; Hsu, Min-Yen; Wang, Meilin; Tsou, Shang-Chun; Chen, Ching-Chung; Lin, Jer-An; Hsiao, Yai-Ping; Lin, Hui-Wen (International Journal of Molecular Sciences, 2021)
Keywords: age-related macular degeneration; Animals; Antioxidants; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; bcl-2-Associated X Protein; bcl-2-Associated X Protein - genetics; Caspase 3; Caspase 3 - genetics; Cell Line; Gene Expression Regulation; Gene Expression Regulation - drug effects; Growth factors; human retinal pigment epithelium; Humans; Iodates; Iodates - toxicity; Kinases; Macular Degeneration; Macular Degeneration - drug therapy; Macular Degeneration - genetics; Macular Degeneration - pathology; Mitochondria; Mitochondria - drug effects; mitochondrial membrane potential; Older people; Oxidative stress; Poly(ADP-ribose) Polymerases; Poly(ADP-ribose) Polymerases - genetics; Proteins; quercetin; Quercetin - pharmacology; Reactive Oxygen Species; Reactive Oxygen Species - metabolism; Retina; Retina - drug effects; Retina - pathology; Retinal Diseases; Retinal Diseases - chemically induced; Retinal Diseases - drug therapy; Retinal Diseases - genetics; Retinal Diseases - pathology; Retinal Pigment Epithelium; Retinal Pigment Epithelium - drug effects; Retinal Pigment Epithelium - growth & development; Signal Transduction; Signal Transduction - drug effects; sodium iodate; Software; Statistical analysis; Variance analysis; St Louis Missouri; Ann Arbor Michigan; United States--US; Japan; apoptosis; quercetin; human retinal pigment epithelium; sodium iodate; age-related macular degeneration; mitochondrial membrane potential