DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma

• Published in: Advanced science Vol. 11; no. 36; pp. e2403262 - n/a
• Main Authors: Li, Qing‐Jie, Fang, Xue‐Liang, Li, Ying‐Qin, Lin, Jia‐Yi, Huang, Cheng‐Long, He, Shi‐Wei, Huang, Sheng‐Yan, Li, Jun‐Yan, Gong, Sha, Liu, Na, Ma, Jun, Zhao, Yin, Tang, Ling‐Long
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2024; John Wiley and Sons Inc; Wiley
• Subjects: Alzheimer's disease; Animals; Apoptosis; Cancer; Cell adhesion & migration; Cell cycle; Cell growth; Cell Line, Tumor; chemoresistance; Chemotherapy; Cisplatin - pharmacology; DCAF7; deubiquitylation; Disease Models, Animal; DNA Helicases - genetics; DNA Helicases - metabolism; Drug Resistance, Neoplasm - genetics; Humans; Medical prognosis; Metastasis; Mice; nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - drug therapy; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Neoplasm Metastasis - genetics; Poly-ADP-Ribose Binding Proteins - genetics; Poly-ADP-Ribose Binding Proteins - metabolism; Proteins; RNA Helicases - genetics; RNA Helicases - metabolism; RNA Recognition Motif Proteins - genetics; RNA Recognition Motif Proteins - metabolism; Tumors; Ubiquitin Thiolesterase - genetics; Ubiquitin Thiolesterase - metabolism; Ubiquitination - genetics; chemoresistance; nasopharyngeal carcinoma; chemotherapy; DCAF7; deubiquitylation

Despite docetaxel combined with cisplatin and 5‐fluorouracil (TPF) being the established treatment for advanced nasopharyngeal carcinoma (NPC), there are patients who do not respond positively to this form of therapy. However, the mechanisms underlying this lack of benefit remain unclear. DCAF7 is i...