Disposition of Oral Nalbuphine and Its Metabolites in Healthy Subjects and Subjects with Hepatic Impairment: Preliminary Modeling Results Using a Continuous Intestinal Absorption Model with Enterohepatic Recirculation - Nagar, Swati; Hawi, Amale; Sciascia, Thomas; Korzekwa, Ken (Metabolites, 2024)
Keywords: Analgesics; Bioavailability; Comparative analysis; Differential equations; Drug dosages; Drug interaction; drug metabolism; enterohepatic recycling; Enzymes; hepatic impairment; Intestinal absorption; Intestine; Isoenzymes; Liver; mechanistic modeling; Metabolism; Metabolites; Nalbuphine; Oral administration; Partial differential equations; Pharmacokinetics; Physiological aspects; Plasma; Proteins; United States--US; hepatic impairment; pharmacokinetics; enterohepatic recycling; nalbuphine; mechanistic modeling; drug metabolism