Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy

• Published in: Marine biotechnology (New York, N.Y.) Vol. 23; no. 1; pp. 149 - 155
• Main Authors: Tzachor, Asaf, Rozen, Or, Khatib, Soliman, Jensen, Sophie, Avni, Dorit
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2021; Springer Nature B.V
• Subjects: acute respiratory distress syndrome; Algae; Animal models; Aquatic plants; Arthrospira platensis; Biomedical and Life Sciences; biotechnology; Cell activation; Cell Extracts - pharmacology; Cell Extracts - therapeutic use; Cells, Cultured; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - therapy; COVID-19 infection; Cyanobacteria; Cytokine Release Syndrome - etiology; Cytokine Release Syndrome - therapy; Cytokine storm; Cytokines; Engineering; Freshwater & Marine Ecology; Humans; In Vitro Techniques; In vivo methods and tests; Life Sciences; Light emitting diodes; Lipopolysaccharides; macrophage activation; Macrophages; Macrophages - drug effects; Microbiology; Monocytes; Monocytes - drug effects; Original; Original Article; photosynthesis; Respiratory distress syndrome; Secretion; Severe acute respiratory syndrome coronavirus 2; Spirulina; Spirulina - chemistry; therapeutics; Tumor necrosis factor-α; Viral diseases; Zoology; COVID-19; Anti TNF-α therapy; Biotechnology; Spirulina; Immunology; Cytokine storm

An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia , commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respirator...