Significance of serum hepatitis C virus RNA levels in chronic hepatitis C

• Published in: The Lancet (British edition) Vol. 341; no. 8859; pp. 1501 - 1504
• Main Authors: Lau, J.Y.N, Davis, G.L, Kniffen, J, Qian, K.-P, Urdea, M.S, Chan, C.S, Neuwald, P.D, Wilber, J.C, Mizokami, M
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 12.06.1993; Lancet; Elsevier Limited
• Subjects: Adult; Aged; Amplification; Base Sequence; Biological and medical sciences; Biopsy; Blood transfusion; Chronic infection; Clinical trials; Deoxyribonucleic acid; DNA; Drug abuse; Female; Hepacivirus - genetics; Hepacivirus - isolation & purification; Hepatitis; Hepatitis C; Hepatitis C - blood; Hepatitis C - drug therapy; Hepatitis C - microbiology; Hepatitis, Chronic - blood; Hepatitis, Chronic - drug therapy; Hepatitis, Chronic - microbiology; Human viral diseases; Humans; Infections; Infectious diseases; Interferon; Interferon alpha-2; Interferon-alpha - therapeutic use; Intravenous administration; Lesions; Liver; Male; Medical personnel; Medical research; Medical sciences; Middle Aged; Molecular Sequence Data; Non-A, non-B hepatitis; Patients; Quantitative research; Recombinant Proteins; Ribonucleic acid; RNA; RNA viruses; RNA, Viral - blood; Viral diseases; Viral hepatitis; Viremia; Viremia - microbiology; Viruses; Workers; α-Interferon; Infection; Virus; Human; Chronic; RNA; Viral disease; Digestive diseases; Exploration; Hepatic disease; Serum; Hepatitis C virus; Viral hepatitis C

Hepatitis C virus (HCV) is the main cause of parenteral non-A, non-B hepatitis and serum can be tested for the virus itself by reverse-transcription polymerase chain amplificaton. What of the level of this viraemia? To find out if quantitative study of H CV RNA might be useful clinically we took adv...