Protein motions and dynamic effects in enzyme catalysis

• Published in: Physical chemistry chemical physics : PCCP Vol. 17; no. 46; pp. 3817 - 3827
• Main Authors: Luk, Louis Y. P, Loveridge, E. Joel, Allemann, Rudolf K
• Format: Journal Article
• Language: English
• Published: England 01.01.2015
• Subjects: Biocatalysis; Catalysis; Catalysts; Catalytic Domain; Coupling; Dynamics; Enzymes; Escherichia coli - enzymology; Escherichia coli - metabolism; Escherichia coli Proteins - chemistry; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Evolution; Kinetics; Mutagenesis, Site-Directed; Proteins; Solvents - chemistry; Tetrahydrofolate Dehydrogenase - chemistry; Tetrahydrofolate Dehydrogenase - genetics; Tetrahydrofolate Dehydrogenase - metabolism; Tuning

The role of protein motions in promoting the chemical step of enzyme catalysed reactions remains a subject of considerable debate. Here, a unified view of the role of protein dynamics in dihydrofolate reductase catalysis is described. Recently the role of such motions has been investigated by charac...