Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study

• Published in: Environment international Vol. 187; p. 108720
• Main Authors: Zhang, Boya, Wang, Zheng, Zhang, Jiming, Dai, Yiming, Ding, Jiayun, Guo, Jianqiu, Qi, Xiaojuan, Wu, Chunhua, Zhou, Zhijun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2024; Elsevier
• Subjects: Bayesian theory; blood serum; Child; cohort studies; confidence interval; environment; homeostasis; Intelligence quotient; maternal exposure; Mediation effect; neurodevelopment; Per- and polyfluoroalkyl substances; perfluorononanoic acid; perfluorooctane sulfonic acid; perfluorooctanoic acid; Thyroid function; triiodothyronine; Umbilical cord blood; ADE; BBB; Umbilical cord blood; GLM; Per- and polyfluoroalkyl substances; PFNA; QC; Pb; Thyroid function; Child; PFDoDA; PFDS; FT3; ACME; LOQs; FT4; IQ; TSH; SMBCS; PFOSA; BKMR; TT3; TT4; ADHD; PFASs; SD; FDR; PFDA; BMI; PFSA; PFBS; Mediation effect; PFHxS; CI; PFUnDA; DNBC; PFHpA; DAG; PFOA; FIQ; PFCA; TE; PIQ; PIPs; WISC-CR; PFHpS; THs; Intelligence quotient; PFOS; VIQ

[Display omitted] •Prenatal PFASs exposure, fetal thyroid function and child’s IQ were assessed.•∑PFCA exposure were negatively associated with performance IQ, especially in girls.•PFASs exposure was associated with higher TT4/TT3 and FT4/FT3.•No significant mediation effect of thyroid function was...