Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1 - Hellmuth, Susanne; Rata, Scott; Brown, Andreas; Heidmann, Stefan; Novak, Bela; Stemmann, Olaf (Molecular cell, 2015)
Keywords: anaphase; Anaphase - genetics; CDC2 Protein Kinase; chromatids; Chromatids - genetics; chromatin; chromosome segregation; Chromosome Segregation - genetics; Cyclin B1 - chemistry; Cyclin B1 - genetics; Cyclin B1 - metabolism; Cyclin-Dependent Kinases - chemistry; Cyclin-Dependent Kinases - genetics; Cyclin-Dependent Kinases - metabolism; cyclins; enzyme inhibition; Gene Expression Regulation, Enzymologic; half life; HEK293 Cells; Humans; Immunoblotting; isomerases; isomerization; Metaphase - genetics; mice; Microscopy, Fluorescence; mitosis; Mitosis - genetics; Models, Genetic; Models, Molecular; Mutation; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase - genetics; Peptidylprolyl Isomerase - metabolism; phosphorylation; Protein Binding; Protein Conformation; proteolysis; RNA Interference; Securin - genetics; Securin - metabolism; separase; Separase - chemistry; Separase - genetics; Separase - metabolism; telophase; ubiquitin