Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds

Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To o...

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Published inNanomaterials (Basel, Switzerland) Vol. 11; no. 10; p. 2593
Main Authors Casanova, Francisca, Pereira, Carla F., Ribeiro, Alessandra B., Freixo, Ricardo, Costa, Eduardo, E. Pintado, Manuela, Fernandes, João C., Ramos, Óscar L.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.10.2021
MDPI
Subjects
Bioactive compounds
Bioavailability
Biocompatibility
Biodegradation
Biological activity
Biomass
Cellulose
delivery systems
Drug delivery systems
Formulations
Functional foods & nutraceuticals
Lignocellulose
liposoluble compounds
microcrystalline cellulose
nanocellulose
Nanocrystals
Nanomaterials
Polymers
Review
Reviews
Solubility
Sustainable development
Toxicity
microcrystalline cellulose
nanocellulose
delivery systems
cellulose
liposoluble compounds
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Abstract Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro- and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro- and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.
AbstractList Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro- and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro- and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro- and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro- and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.
Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro- and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro- and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.
Author Fernandes, João C.
E. Pintado, Manuela
Pereira, Carla F.
Ribeiro, Alessandra B.
Costa, Eduardo
Casanova, Francisca
Freixo, Ricardo
Ramos, Óscar L.
AuthorAffiliation CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal; fcbastos@ucp.pt (F.C.); abribeiro@porto.ucp.pt (A.B.R.); rfreixo@ucp.pt (R.F.); emcosta@ucp.pt (E.C.); mpintado@ucp.pt (M.E.P.); jcfernandes@porto.ucp.pt (J.C.F.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34685034$$D View this record in MEDLINE/PubMed
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Issue 10
Keywords microcrystalline cellulose
nanocellulose
delivery systems
cellulose
liposoluble compounds
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds...
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SubjectTerms Bioactive compounds
Bioavailability
Biocompatibility
Biodegradation
Biological activity
Biomass
Cellulose
delivery systems
Drug delivery systems
Formulations
Functional foods & nutraceuticals
Lignocellulose
liposoluble compounds
microcrystalline cellulose
nanocellulose
Nanocrystals
Nanomaterials
Polymers
Review
Reviews
Solubility
Sustainable development
Toxicity
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  providerName: Directory of Open Access Journals
Title Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds
URI https://www.ncbi.nlm.nih.gov/pubmed/34685034
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Volume 11
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