Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis

• Published in: International Journal of Molecular Sciences Vol. 18; no. 5; p. 954
• Main Authors: Lu, Chien-Yi, Chang, Yi-Chih, Hua, Chun-Hung, Chuang, Chieh, Huang, Su-Hua, Kung, Szu-Hao, Hour, Mann-Jen, Lin, Cheng-Wen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2017; MDPI
• Subjects: Anilides; Anilides - pharmacology; Animals; Antiviral Agents; Antiviral Agents - pharmacology; Cell Line; Cell Line, Tumor; Cricetinae; Cricetulus; Encephalitis; Encephalitis Viruses, Japanese; Encephalitis Viruses, Japanese - drug effects; Encephalitis Viruses, Japanese - physiology; Histone Deacetylase 6; Histone Deacetylase 6 - antagonists & inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylase Inhibitors - pharmacology; HSP90 Heat-Shock Proteins; HSP90 Heat-Shock Proteins - metabolism; Humans; Hydroxamic Acids; Hydroxamic Acids - pharmacology; Japanese encephalitis virus; histone deacetylase 6; tubacin; heat shock protein 90 (Hsp90); non-structural protein 5 (NS5); RNA, Viral; RNA, Viral - metabolism; Vaccines; Viral Nonstructural Proteins; Viral Nonstructural Proteins - metabolism; Virus Replication; Virus Replication - drug effects; Japanese encephalitis virus; heat shock protein 90 (Hsp90); non-structural protein 5 (NS5); tubacin; histone deacetylase 6

Japanese encephalitis virus (JEV), a neurotropic flavivirus, annually causes over 30,000 Japanese Encephalitis (JE) cases in East and Southeast Asia. Histone deacetylases (HDACs) modulate lysine acetylation of histones and non-histone proteins, regulating many processes including inflammation and an...