Long-Term Consumption of Sucralose Induces Hepatic Insulin Resistance through an Extracellular Signal-Regulated Kinase 1/2-Dependent Pathway - Tsai, Meng-Jie; Li, Chung-Hao; Wu, Hung-Tsung; Kuo, Hsin-Yu; Wang, Chung-Teng; Pai, Hsiu-Ling; Chang, Chih-Jen; Ou, Horng-Yih (Nutrients, 2023)
Keywords: Animals; Artificial sweeteners; blood glucose; Cardiovascular disease; Cell culture; Cell cycle; Cell growth; Dextrose; Diabetes; Diabetes therapy; Diet; Diet, High-Fat - adverse effects; endoplasmic reticulum stress; Enzymes; Glucose; Glucose Intolerance - etiology; glycemic control; high fat diet; Homeostasis; Insulin; Insulin Resistance; insulin secretion; Kinases; Laboratory animals; liver; Liver - metabolism; Lymphocytes; Metabolism; Mice; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 3; Obesity; Oxidative stress; Proteins; R&D; Research & development; Sucralose; Sweetening Agents - pharmacology; taste receptors; Taiwan; St Louis Missouri; United States--US; Taste 1 receptor member 3; artificial sweetener; insulin resistance; high-fat diet; sucralose