Histological and functional outcomes in a rat model of hemisected spinal cord with sustained VEGF/NT-3 release from tissue-engineered grafts

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 48; no. 1; pp. 362 - 376
• Main Authors: Xu, Zi-Xing, Zhang, Li-Qun, Zhou, Yi-Nan, Chen, Xue-Min, Xu, Wei-Hong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Angiogenesis; Bone growth; Gliosis; Growth factors; Inflammation; Mesenchyme; Microvasculature; neural repair; Neurotrophin 3; neurotrophin-3 (NT-3); poly (lactic-co-glycolic acid) (PLGA) nanoparticles; Recovery; Spinal cord; Spinal cord injuries; Spinal cord injury (SCI); Stem cell transplantation; Stem cells; Tissue engineering; Transplantation; Vascular endothelial growth factor; vascular endothelial growth factor (VEGF); Spinal cord injury (SCI); vascular endothelial growth factor (VEGF); poly (lactic-co-glycolic acid) (PLGA) nanoparticles; neural repair; neurotrophin-3 (NT-3); angiogenesis

Microvascular disturbance, excessive inflammation and gliosis are key pathophysiologic changes in relation to functional status following the traumatic spinal cord injury (SCI). Continuous release of vascular endothelial growth factor (VEGF) to the lesion site was proved be able to promote the vascu...